Neuroleptic malignant syndrome(NMS) is an uncommon but potentially fatal
idiosyncratic reaction to neuroleptics, characterized by muscular rigidity, fever, autonomic
dysfunction, and altered consciousness. The major theories to explain NMS is central
dopaminergic blockade, but it is unclear. Risperidone is a new antipsychotic drug, a
benzisoxazole derivative that blocks dopamine D2 receptor and serotonin
type 2 receptor. The comparatively greater serotonin-blocking activity is believed to give
risperidone the specific property of not causing any more extrapyramidal side effects
than conventional antipsychotics at the optimal dose of 4-8mg/day. It is postulated that
risperidone is unlikely to cause NMS. Here, we report a case of risperidone induced
neuroleptic malignant syndrome.
|